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ECP in the treatment of acute and chronic GvHD: Guided case studies

By Devon Else

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Feb 4, 2026

Learning objective: After reading this article, learners will be able to describe and identify patient-related factors relevant to the selection of extracorporeal photopheresis for the treatment of acute and chronic graft-versus-host disease.


Do you know... A patient with which organ manifestation of GvHD would be most appropriate for treatment with ECP?

Question 1 1

Knowledge check | According to SIdEM and GITMO recommendations, when should response to ECP be measured in patients with cGvHD?

A

Every 3 weeks

B

Every 2 weeks

C

Every week

D

Every month

Extracorporeal photopheresis (ECP) is typically considered as a second-line or later treatment option for patients with acute or chronic graft-versus-host disease (GvHD) who do not respond to corticosteroids or other immunosuppressive treatments or who experience relapse after an initial response and are therefore classified as having steroid-refractory (SR) GvHD.

In the final chapter of this e-learning module, explore two patient case studies to navigate the GvHD treatment journey, including patient selection and treatment sequencing with ECP in both acute and chronic GvHD.

Click through the slides below to explore the first patient case study in acute GvHD.

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Question 1 1

Knowledge check | Which of the following statements best describes the rationale for ECP for the treatment of aGvHD?

A

It is an immunomodulatory and steroid-sparing therapy

B

It is an immunosuppressive therapy

C

It enables increased steroid dosing

D

It is primarily a supportive care measure, in combination with other agents

Click through the slides below to explore the second patient case study in chronic GvHD.

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These patient case studies were provided by Florent Malard.

This educational resource is independently supported by Therakos. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource. 

Your opinion matters

Which consideration most strongly guides your decision to escalate therapy in SR-aGvHD?