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Guidelines and recommendations for the use of ECP in the treatment of GvHD

By Devon Else

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Jan 27, 2026

Learning objective: After reading this article, learners will be able to recall the latest guidelines and expert recommendations for the use of extracorporeal photopheresis in the treatment of both acute and chronic graft-versus-host disease.


Do you know... According to the SIdEM and GITMO recommendations, which statement best describes the optimal ECP treatment cycle for patients with cGvHD?

Question 1 1

Knowledge check | In a retrospective study by Lastovytska et al., what was the CR rate at Month 6 in patients with SR-aGvHD treated with ECP + ruxolitinib?

A

25%

B

40%

C

50%

D

65%

There is heterogeneity between treatment centers regarding extracorporeal photopheresis (ECP) scheduling, and the optimal treatment schedule for ECP in graft-versus-host disease (GvHD) is yet to be determined. 

In the third chapter of this e-learning module, we provide an overview of the current guidelines and latest recommendations from expert groups, including the American Society for Apheresis (ASFA), alongside multiple European groups from Italy, Germany, and the UK, for the use of ECP for the treatment of acute and chronic GvHD.  

Click through the slides below to learn more. 

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The next chapter of this e-learning module will be published shortly. 

This educational resource is independently supported by Therakos. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.

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