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Acute graft-versus-host disease

Acute graft-versus-host disease

Acute graft-versus-host disease (aGvHD) is a major complication following allogeneic hematopoietic stem cell transplant and a leading cause of early non-relapse mortality. It usually develops within the first 100 days after transplantation and typically affects the skin with a maculopapular rash, the gastrointestinal tract with nausea and emesis, and/or the liver causing elevated serum bilirubin concentrations.