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2024-07-15T12:29:56.000Z

Symposium | The long-term burden of cGvHD

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Jul 15, 2024
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Learning objective: After watching this video, learners will be able to identify which patients will benefit from ECP.

Test your knowledge! Take our quick quiz before and after you read this article to find out if you improved your knowledge. Results help us to improve content and continually provide open-access education.

On April 14, 2024, the GvHD Hub held a symposium at the 50th European Society for Bone and Marrow Transplantation (EBMT) Annual Meeting on the role of extracorporeal photopheresis (ECP) in the management of chronic graft-versus-host disease (cGvHD). 

Here, we share the presentation by Bipin Savani, Vanderbilt University Medical Center, Nashville, US, which explored the long-term burden of cGvHD. Savani discussed organs frequently affected by cGvHD (Figure 1), comorbidities and mortality in patients with cGvHD (Figure 2), and recent progress made in improving the safety of transplantation. He highlighted that mental health disorders, such as anxiety and depression, are prevalent in patients with cGvHD and that the physical burden of symptoms contributes to limitation of daily activities in these patients. 

Figure 1. Proportion of patients experiencing mouth, skin, liver, and eye symptoms of cGvHD*

cGvHD, chronic graft-versus-host disease. 
*Data from Kurosawa et al.1 and Arora et al.2 



Figure 2. Causes of death in long-term survivors of cGvHD*

cGvHD, chronic graft-versus-host disease. 
*Adapted from Martin et al.3 

 
Q&A session 

This symposium closed with a panel Q&A session with live audience participation, where our panelists shared their perspectives on the value and challenges of ECP in pediatric patients. 

Symposium | Q&A | Value and challenges of ECP in pediatric patients

Symposium | The long-term burden of cGvHD

  1. Kurosawa S, Oshima K, Yamaguchi T, et al. Quality of life after allogeneic hematopoietic cell transplantation according to affected organ and severity of chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2017;23(10):1749-1758. DOI: 10.1016/j.bbmt.2017.06.011 
  2. Arora M, Cutler CS, Jagasia MH, et al. Late acute and chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2016;22(3):449-455. DOI: 10.1016/j.bbmt.2015.10.018
  3. Martin PJ, Counts Jr GW, Appelbaum FR, et al. Life expectancy in patients surviving more than 5 years after hematopoietic cell transplantation. J Clin Oncol. 2010;28(6):1011-1016. DOI: 10.1200/JCO.2009.25.6693

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