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Symposium | A brief overview and history of ECP
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GvHD Hub EBMT Symposium 2024: 30 years of ECP in GvHD: Recommendations for the treatment of cGvHD
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On April 14, 2024, the GvHD Hub held a symposium at the 50th European Society for Bone and Marrow Transplantation (EBMT) Annual Meeting on the role of extracorporeal photopheresis (ECP) in the management of chronic graft-versus-host disease (cGvHD).
Here, we share the presentation by Mohamad Mohty, Hôpital Saint-Antoine and Sorbonne Université, Paris, FR, which explored a brief history of ECP, outlined the allogeneic hematopoietic stem cell transplantation (Figure 1) and ECP procedures (Figure 2), and also included two cGvHD patient case studies.
Figure 1. The allo-HSCT procedure*
aGvHD, acute graft-versus-host disease; allo-HSCT, allogeneic hematopoietic stem cell transplantation; cGvHD, chronic graft-versus-host disease; CMV, cytomegalovirus; GvHD, graft-versus-host disease.
*Adapted from Mohty, et al.2 Created with Biorender.com.
Figure 2. What is ECP?
ECP, extracorporeal photopheresis; GvHD, graft-versus-host disease; UVA, ultraviolet A.
*Adapted from Knobler R, et al.3 Created with Biorender.com
Q&A session
This symposium closed with a panel Q&A session with live audience participation, where our panelists shared their perspectives on the impact of ECP on the GvHD treatment landscape and the importance of early intervention in GvHD treatment.
Symposium | Q&A | Impact of ECP on the GvHD treatment landscape
This independent educational activity was supported by Mallinckrodt Pharmaceuticals. All content was developed independently by the faculty. The funder was allowed no influence on the content of this activity.
- Malard F, Chevallier P, Guillaume T, et al. Continuous reduced nonrelapse mortality after allogeneic hematopoietic stem cell transplantation: A single-institution’s three decade experience. Biol Blood Marrow Transplant. 2014;20(8):1217-1223. DOI: 10.1016/j.bbmt.2014.04.021
- Mohty M, Florent M. Increasing donor options in allogenic hematopoietic cell transplantation. J Clin Oncol. 2021;20;39(18):1951-1954. DOI: 10.1200/JCO.21.00622
- Knobler R, Barr ML, Couriel DR, et al. Extracorporeal photopheresis: Past, present, and future. J Am Acad Dermatol. 2009;61(4):652-665. DOI: 10.1016/j.jaad.2009.02.039
Video series
GvHD Hub EBMT Symposium 2024: 30 years of ECP in GvHD: Recommendations for the treatment of cGvHD
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