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Endothelial protection
Endothelial protection
The endothelium plays a key role in the maintenance of tissue homeostasis, regulating local blood flow, and other physiological processes. Chemotherapy and GvHD may induce endothelial dysfunction, eventually leading to damage of organs, such as the gut, liver, and kidneys. Endothelial protection aims to improve endothelial function, reduce the risk of inflammatory cytokine release, inhibit immune activation, and prevent organ damage.