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Calcineurin inhibitors inhibit the phosphatase activity of calcineurin, an enzyme involved in the regulation of interleukin-2 (IL-2) production and IL-2 receptor expression, and therefore affect T-cell activation and cell-mediated immunity. Some calcineurin inhibitors can be applied both topically and systemically. Examples of calcineurin inhibitors include tacrolimus, pimecrolimus, and cyclosporin A.