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Calcineurin inhibitors can be used alongside donor regulatory T cells (Tregs) for the prevention of graft-versus-host disease (GvHD) in patients who undergo allogeneic hematopoietic cell transplantation (allo-HCT). Regulatory T cells restrain excessive immune responses in patients and have shown promise as a form of GvHD prophylaxis. However, it remains unclear if the addition of immunosuppressive prophylaxis, for example with single agent tacrolimus (TAC), adds any GvHD preventative benefit to the use of a Treg graft alone.
Here, we summarize an article by Bader et al.,1 published in Blood Advances, evaluating the use of T-reg graft vs Treg graft + TAC for the prevention of acute GvHD (aGvHD) (NCT01660607).
Table 1. Cumulative incidence of GvHD in patients who received Treg graft vs Treg graft + TAC*
|
Treg graft |
Treg graft + TAC |
p value |
---|---|---|---|
Grade 2─4 aGvHD |
58.3% |
8.3% |
p = 0.006 |
Grade 3─4 aGvHD |
17% |
0% |
p = 0.149 |
Moderate-to-severe cGvHD at 1 year |
28.4% |
0.0% |
p = 0.058 |
aGvHD, acute graft-versus-host disease; cGvHD, chronic GvHD; TAC, tacrolimus; Treg; T-regulatory cell. |
Key learnings |
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