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Masterclass | ECP for treating SR-GvHD: Clinical insights and future directions

By Beth Campbell

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Robert ZeiserRobert ZeiserHildegard GreinixHildegard GreinixDaniel WolffDaniel Wolff

Oct 29, 2026

Learning objective: After reading this article, learners will be able to describe the evolving role of extracorporeal photopheresis in the treatment of steroid-refractory graft-versus-host disease, including key clinical considerations for its use.


Extracorporeal photopheresis (ECP) is a leukapheresis-based procedure used to treat acute and chronic graft-versus-host disease (GvHD), particularly in the setting of steroid-refractory (SR) GvHD, due to its immunomodulatory mechanism of action, favorable safety profile, and steroid-sparing efficacy.1–3 

The GvHD Hub spoke with Daniel Wolff, Hildegard Greinix, and Robert Zeiser to gain their expert insights into the role of ECP for the treatment of SR-GvHD, including unmet needs, key clinical considerations for ECP use, and how it should be positioned in the evolving GvHD treatment landscape. 

What are the key clinical considerations for the use of ECP in steroid-refractory GvHD?

What are the key clinical considerations for the use of ECP in steroid-refractory GvHD?

The GvHD Hub spoke with Daniel Wolff, University Hospital Regensburg, Regensburg, DE. We asked, What are the key clinical considerations for the use of ECP in steroid-refractory GvHD?

What are the ongoing unmet needs in SR-GvHD, and how can ECP potentially address these?

What are the ongoing unmet needs in SR-GvHD, and how can ECP potentially address these?

The GvHD Hub spoke with Hildegard Greinix, Medical University of Vienna, Vienna, AT. We asked, What are the ongoing unmet needs in SR-GvHD, and how can ECP potentially address these?

How can ECP be positioned in the current GvHD treatment landscape as a steroid-free intervention?

How can ECP be positioned in the current GvHD treatment landscape as a steroid-free intervention?

The GvHD Hub spoke with Robert Zeiser, University of Freiburg, Freiburg, DE. We asked, How can ECP be positioned in the current GvHD treatment landscape as a steroid-free intervention?

This educational resource is independently supported by Therakos. All content is developed by SES in collaboration with an expert steering committee. Funders are allowed no influence.   

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This content is accurate as of the date of publication and is not updated retrospectively. Please refer to the latest available evidence, guidelines, and relevant regulatory information when making clinical decisions.