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On November 29, 2022, the GvHD Hub held a virtual symposium on the role of extracorporeal photopheresis (ECP) in the management of graft-versus-host disease (GvHD).
Here, we share the presentation given by Mohamad Mohty, Hôpital Saint-Antoine and Sorbonne Université, Paris, FR, which explored the key considerations for the use of ECP in GvHD.
In this presentation, Mohty discusses what is the most appropriate treatment approach in specific cases of acute GvHD (aGvHD) and chronic GvHD (cGvHD) post-allogenic stem cell transplant (allo‑HSCT). Using example cases paired with clinical data, this presentation evaluated the use of ECP plus steroids by assessing the safety and response rates as a first-line treatment option for aGvHD. Mohty then outlines indications for second-line therapy of cGvHD by discussing progression, disease stability, and the intolerance of first-line treatment of ECP plus steroids. Finally, the floor is opened to allow the panel to discuss supportive care options in cGvHD, in which they cover the themes summarized in Figure 1.
Figure 1. Areas of supportive care needed in chronic GvHD*
GvHD, graft-versus-host-disease; Ig, immunoglobulin; IV, intravenous; VZV, varicella zoster virus.
*Mohamad Mohty. Personal communication; Nov 29, 2022.
Watch the presentation to learn more about the key considerations for the use of ECP in GvHD, including:
This independent educational activity was supported by Mallinckrodt Pharmaceuticals. All content was developed independently by the faculty. The funder was allowed no influence on the content of this activity.
To download the slides presented, click here.Download here
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