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Visual abstract | Ruxolitinib versus basiliximab in adult patients with steroid-refractory aGvHD
Acute graft-versus-host disease (aGvHD) occurs in approximately 30–50% of patients who receive allogeneic hematopoietic stem cell transplantation (allo-HSCT).1
Although glucocorticoids are the standard first-line treatment, they fail to yield a response in almost 60% of patients; outlining the need for second-line treatment options.1 The current recommended second-line treatment for steroid-refractory aGvHD is ruxolitinib, a JAK inhibitor, with basiliximab also considered a feasible salvage therapy option.1
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