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Ruxolitinib in combination with belumosudil for patients with treatment-refractory cGvHD
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Treatment for patients with cGvHD beyond second-line therapy typically includes multiple agents with the aim of tapering systemic steroids.1 Both ruxolitinib and belumosudil are effective therapies that allow steroid tapering; however, data on the use of these therapies in combination are limited.1 A single-center, retrospective analysis assessed the safety and efficacy of ruxolitinib plus belumosudil in 20 treatment-refractory patients with cGvHD.1 Results from this analysis were published in Leukemia & Lymphoma by Caputo et al.1 |
| Key learnings |
| The ORR was 55%, with CR, PR, and initial PR then progression rates of 5%, 35%, and 15%, respectively. |
| Ruxolitinib plus belumosudil facilitated immunosuppressive agent tapering or discontinuation in all responders, highlighting its potential as a steroid-sparing option in refractory cGvHD management. |
| Treatment was well tolerated, with no discontinuations due to toxicity, indicating a favorable safety profile. Grade ≥3 pneumonia and viral URI were observed in 20% and 10% of patients, respectively, and there were no patients with CMV or EBV requiring treatment. |
| The combination of ruxolitinib and belumosudil was well-tolerated, delayed the need for alternative therapies, and facilitated the tapering of immunosuppressive therapies. Responses were observed in patients with progression after monotherapy with both agents, suggesting a potential synergistic effect. |
Abbreviations: cGvHD, chronic graft-versus-host disease; CMV, cytomegalovirus; CR, complete response; EBV, Epstein-Barr virus; ORR, overall response rate; PR, partial response; URI, upper respiratory infection.
- Caputo J, Peddireddi A, Bhatta S, et al. Combination ruxolitinib and belumosudil is tolerable and induces responses despite treatment failure as monotherapies. Leuk Lymphoma. 2024. Online ahead of print. DOI: 1080/10428194.2024.2409876
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