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PTCy as a prophylaxis regimen for patients with Hodgkin lymphoma
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Data from 176 patients with Hodgkin lymphoma (HL) treated with post-transplant cyclophosphamide (PTCy) and 270 patients with conventional calcineurin inhibitor (CNI)-based graft-versus-host disease (GvHD) prophylaxis regimens were published in Blood Advances by Montori et al.1
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The incidence of chronic GvHD was lower in the PTCy cohort compared with the CNI-based cohort (25% vs 43%; p < 0.001). |
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Patients treated with PTCy experienced a lower 2-year cumulative incidence of relapse compared with those treated with CNI-based prophylaxis (17% vs 30%; p = 0.007). |
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Improved overall survival rates were observed with PTCy compared with CNI-based prophylaxis (85% vs 72%; p = 0.005). |
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Progression-free survival (72% vs 53%; p < 0.001) and GvHD-free relapse-free survival rates (59% vs 31%; p < 0.001) were also higher in the PTCy cohort compared with CNI-based cohort. |
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Overall, PTCy prophylaxis resulted in a lower incidence of GvHD, as well as improved clinical outcomes in patients with HL undergoing transplant from human leukocyte antigen-matched donors. |
- Montoro J, Ngoya M, Kulagin A, et al. PTCy vs CNI-based GVHD prophylaxis in HLA-matched transplants for Hodgkin lymphoma: A study of the LWP of the EBMT. Blood Adv. 2024;8(15):3985-3992. DOI: 1182/bloodadvances.2024013328.
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