All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional.

The GvHD Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

An expert panel hosted by

Customizing first-line BTK inhibitors for CLL

with Gilles Salles, Paolo Ghia, and Francesc Bosch

Wednesday, October 23, 2024
18:30-19:30 BST

Register now

This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.

  TRANSLATE

The GvHD Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the GvHD Hub cannot guarantee the accuracy of translated content. The GvHD Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

Steering CommitteeAbout UsNewsletterContact
LOADING
You're logged in! Click here any time to manage your account or log out.
LOADING
You're logged in! Click here any time to manage your account or log out.

The GvHD Hub is an independent medical education platform, sponsored by Medac and supported through grants from Sanofi and Therakos. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.

2024-06-12T09:53:03.000Z

Prediction of response and long-term outcomes of second-line therapy for patients with aGvHD: A MAGIC analysis

Jun 12, 2024
Share:
Learning objective: After reading this article, learners will be able to cite a new clinical development in acute GvHD.


An analysis evaluating the association between the Mount Sinai Acute Graft-versus-Host Disease (aGvHD) International Consortium (MAGIC) algorithm probabilities (MAP), measured at the initiation of second-line therapy, and Day 28 response and long-term outcomes, in patients with aGvHD, was published in Blood Advances by DeFilipp et al.1 Clinical data and serum samples from 167 patients who received second-line systematic treatment for aGvHD between January 2016 and December 2021 were analyzed from the MAGIC database and biorepository.1  


Key learnings:
Compared with other second-line therapies for aGvHD, ruxolitinib was associated with improved outcomes (Day 28 overall response: 55% vs 31%, p=0.003; 2-year non-relapse mortality [NRM] point estimates: 12% vs 41%; 2-year overall survival [OS] point estimates: 79% vs 52%); however, this benefit was limited to patients with low MAP. 
For lower-risk patients (low MAP) at initiation of second-line therapy, ruxolitinib should be considered standard of care; however, for higher-risk patients (high MAP), exploring new therapies or combination treatments in clinical trials is warranted to improve outcomes. 
Therefore, MAP at initiation of second-line therapy for aGVHD is a significant predictor of NRM and overall survival (OS). 
Overall, despite the studys retrospective nature and limited sample size, these findings suggest that integrating MAP into clinical practice could personalize treatment approaches for aGVHD, optimizing therapeutic strategies and improving patient outcomes. 
In addition, incorporating MAP into clinical trial designs for steroid-refractory aGVHD could enhance the relevance of trial outcomes, particularly in non-randomized studies. 


  1. DeFilipp Z, Kim HT, Spyrou N, et al. The MAGIC algorithm probability predicts treatment response and long-term outcomes to second-line therapy for acute GVHD. Blood Adv. 2024. Online ahead of print. DOI:10.1182/bloodadvances.2024012561 

Your opinion matters

HCPs, what is your preferred format for educational content on the GvHD Hub?
4 votes - 57 days left ...

Newsletter

Subscribe to get the best content related to GvHD delivered to your inbox