The gvhd Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the gvhd Hub cannot guarantee the accuracy of translated content. The gvhd and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The GvHD Hub is an independent medical education platform, sponsored by Medac and supported through grants from Sanofi and Therakos. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View gvhd content recommended for you
Approximately 20–50% of transplanted pediatric patients develop graft-versus-host disease (GvHD), which is the main cause of morbidity and mortality after allogeneic stem cell transplantation (allo-HSCT). Second-line therapeutic options are limited for patients who are resistant to corticosteroid treatment. The use of mycophenolate mofetil (MMF) as prophylaxis and therapy for children undergoing allo-HSCT requires further investigation.1 In the International Journal of Hematology, Nozomu Kawashima et al. published their study evaluating the safety and efficacy of MMF in the prevention and treatment of pediatric GvHD, using a nationwide retrospective survey in Japanese children undergoing allo-HSCT between 1995 and 2011.2
In summary, this Japanese nationwide retrospective analysis showed that MMF is safe and effective as prophylaxis and treatment of pediatric GvHD. The authors added that “further prospective randomized studies including the pharmacokinetics are necessary to determine the optimal MMF dose and combination therapy for GvHD in children.”
References