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MSCs in GvHD and key MSC-FFM safety data

By Devon Else

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Nov 5, 2025

Learning objective: After reading this article, learners will be able to describe the immunomodulatory mechanisms of MSCs in GvHD and summarize key MSC-FFM safety data.


Do you know... Which mechanism best describes how mesenchymal stromal cells (MSCs) exert therapeutic effects in GvHD?

Graft-versus-host disease (GvHD) remains a major complication following allogeneic hematopoietic stem cell transplantationMesenchymal stromal cells (MSCs) have been studied as a potential therapy due to their immunomodulatory and anti-inflammatory properties. MSC-FFM, a standardized, pooled bone marrow-derived MSC product, has been evaluated in patients with refractory acute GvHD across multiple real-world cohorts. 

Our educational mini-module reviews the mechanism of action of MSCs in GvHD and key safety data for MSC-FFM.

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This educational resource is independently supported by Medac. All content was developed by SES in collaboration with an expert steering committee.  Funders were allowed no influence on the content. 

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