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Key findings from a retrospective study investigating ruxolitinib + ECP in SR-aGvHD
Do you know... In a recent retrospective study of ruxolitinib + ECP vs ruxolitinib alone for the treatment of SR-GvHD, at what point did the addition of ECP result in a higher overall response rate (ORR) vs ruxolitinib alone?
High-dose glucocorticoids are the standard of care for first-line treatment of GvHD; however, not all patients experience a sustained response. Ruxolitinib is approved for the treatment of steroid-refractory (SR)-GvHD, but studies suggest that long-term disease control remains an unmet need. Therefore, novel strategies, including combination therapies, are of clinical interest. Key findings from a German retrospective study by Lastovytska et al. have been published in Haematologica, demonstrating long-term outcomes with ruxolitinib + extracorporeal photopheresis (ECP) vs ruxolitinib alone in SR-acute GvHD.
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