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Co-occurrence of inflammation and fibrosis in cGvHD

By Ella Dixon

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Apr 11, 2025

Learning objective: After reading this article, learners will be able to describe the role of the inflammatory pathway in cGvHD, and explain the impact of fibrosis and its associated conditions.


Question 1 1

Chronic GvHD can result in inflammation and tissue damage. Which cells are recruited from the blood by chemokines and cause cytolytic damage to tissues?

A

Th1 and Th17 cells

B

Th2 cells

C

Tc1 cells

D

Treg and Th2 cells

⭐GvHD Hub spotlight: Inflammation and fibrosis in cGvHD⭐

Inflammation in chronic graft-versus-host disease (GvHD) can occur alongside fibrotic manifestations, which can severely impact quality of life. Belumosudil, a ROCK2 inhibitor, has shown efficacy in treating a chronic GvHD patient population with fibrotic manifestations and multiple organ involvement. 

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This educational resource is independently supported by Sanofi. All content was developed by SES in collaboration with an expert steering committee; funders were allowed no influence on the content of this resource. 

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