The gvhd Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the gvhd Hub cannot guarantee the accuracy of translated content. The gvhd and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The GvHD Hub is an independent medical education platform, sponsored by Medac and supported through grants from Sanofi and Therakos. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out more
Create an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View gvhd content recommended for you
Association between vitamins A, D, E, and K and the risk of GvHD post transplant
|
Fat-soluble vitamins A, D, E, and K have been shown to modulate immune responses, but there is limited evidence on the role of these vitamins in GvHD.1 A two-armed RCT that investigated nutritional intervention in 117 adult patients undergoing allo-HSCT following myeloablative conditioning (NCT01181076) was conducted at Oslo University Hospital from 2010 to 2017. Plasma levels of vitamins A, D, E, and K were measured at baseline, 3 and 6 weeks, and 3, 6, 9, and 12 months post transplant.1 A secondary analysis of data from this trial published in Scientific Reports by Skaarud et al.1 assessed the association between vitamin levels and the development of GvHD. |
| Key learnings |
| Higher levels of vitamin E over time were significantly associated with a reduced risk of severe acute GvHD (Grades 3–4). No significant associations were found between vitamin levels (A, D, E, K) and the risk of chronic GvHD. |
| Plasma levels of vitamins A, D, E, and K fluctuated significantly during the first year post allo-HSCT, but only vitamin A was significantly higher in patients receiving enhanced nutritional support (p = 0.010). |
| Given the observed association between vitamin E and less severe acute GvHD, supplementation with vitamin E could be explored as a potential strategy to mitigate post-transplant complications. |
| The study was not designed to assess the direct impact of vitamin supplementation, and additional research is required to determine whether vitamin E supplementation could be a viable preventive strategy in allo-HSCT patients. |
Abbreviations: allo-HSCT, allogeneic hematopoietic stem cell transplant; GvHD, graft-versus-host disease; RCT, randomized controlled trial.
References
Please indicate your level of agreement with the following statements:
The content was clear and easy to understand
The content addressed the learning objectives
The content was relevant to my practice
I will change my clinical practice as a result of this content
