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The 60th American Society of Hematology (ASH) Annual Meeting was held in San Diego, California, from 1–4 December 2018. On Saturday 1 December 2018, an oral abstract session was held entitled: 722. Clinical Allogeneic Transplantation: Acute and Chronic GvHD, Immune Reconstitution: GvHD Grading and Outcomes and Management. During this session, Abstract #67 was presented entitled: Validation of Minnesota Acute GvHD Risk Score and Identification of New Factors Associated with Initial Response to Steroids: Not All GvHD Is Created Equal and was presented by Margaret L. MacMillan from the University of Minnesota, Minneapolis, MN, USA.
Professor MacMillan began by outlining the recently reported Minnesota Acute GvHD Risk Score which is categorising patients based on involved organs and severity of acute graft-versus-host disease (GvHD) at diagnosis. MacMillan and colleagues established a new clinical Minnesota refined risk score that was better than the IBMTR scale to predict overall response rate (ORR) to treatment and 6-month OS. In order to validate the risk score, MacMillan et al. studied a new group of patients with acute GvHD at the University of Minnesota between 2007 and 2016.
Professor MacMillan concluded by stating that this analysis confirms that the Minnesota Acute GvHD Risk Score is a “valuable and immediately available bedside tool to define risk in patients with acute GvHD.” She further added that these findings also confirm the importance of graft source and HCT-CI outcomes after treatment of GvHD. Further studies are required to assess why UCB recipients with acute GvHD have better response rates to steroid therapy and have lower risk of chronic GvHD than other patients with the same risk score undergoing transplantation.
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