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Programmed cell death protein-1 (PD-1) inhibition has previously been shown to induce responses in patients with relapsed or refractory (R/R) lymphoproliferative neoplasms,1 acute myeloid leukemia (AML), and myelodysplastic syndromes (MDS).2 Patients who failed this treatment and subsequently relapse, typically undergo allogeneic hematopoietic cell transplantation (allo-HCT). However, concerns have been raised on the safety of using anti-PD-1 inhibitors before transplantation due to a potential increased risk of graft-versus-host disease (GvHD) by enhancing effector T-cell response; although there is evidence suggesting better graft-versus-leukemia effect with prior use of PD-1 blockade in the same setting. GvHD prophylaxis with posttransplant cyclophosphamide (PTCy) have been shown to suppress clonal alloreactive effector T cells and enhance the role of regulatory T cells (Tregs), which could counterbalance the effect of PD-1 inhibition.1
In the first study recently published in Leukemia, Juan Nieto and colleagues compared PTCy-based GvHD prophylaxis with tacrolimus/sirolimus in patients with non-Hodgkin lymphoma (NHL) treated with an anti-PD-1 inhibitor, nivolumab, prior to allo-HCT.1 Similarly, a second study was published in Cancer (Betül Oran et al.), which is a retrospective investigation on the outcomes after GvHD prophylaxis with PTCy in patients with AML and/or MDS who were treated with an anti-PD-1, and/or an anti-cytotoxic T-lymphocyte-associated protein 4, monoclonal antibodies prior to transplant.2 Herein we will be providing data from both these studies.
Nieto et al.: Comparing GvHD prophylaxis with PTCy vs tacrolimus/sirolimus in allo-transplanted patients with NHL who had received prior therapy with nivolumab
Table 1. A comparison of the outcomes with nivolumab exposure and PTCy/tacrolimus treatment in terms of safety and efficacy1
aGvHD, acute graft-versus-host disease; Sir, sirolimus; Tac, tacrolimus; MMF, mycophenolate mofetil; PTCy, posttransplant cyclophosphamide |
|||||
Patients |
Nivolumab exposure |
GvHD prophylaxis |
aGvHD |
Disease relapse |
Outcome |
---|---|---|---|---|---|
3 |
Exposed |
Tac/Sir |
3 |
0 |
Dead (3) |
3 |
Exposed |
Sir/MMF/PTCy |
0 |
2 |
Alive (2), dead (2) |
6 |
naïve |
Tac/Sir |
1 |
0 |
Alive (6) |
6 |
naïve |
Sir/MMF/PTCy |
2 |
1 |
Alive (3), dead (3) |
Betül Oran et al.: PTCy improves transplantation outcomes in patients with AML/MDS previously treated with checkpoint inhibitors
Table 2. A comparison of the outcomes with prior CPI exposure and PTCy treatment2
Allo-HCT, allogeneic hematopoietic cell transplantation; CPI, checkpoint inhibitor; NRM, non-relapse mortality; OS, overall survival; PFS, progression-free survival; PTCy, posttransplant cyclophosphamide |
||||
|
Prior CPI to allo-HCT + PTCy (n = 22) |
Prior CPI to allo-HCT + no PTCy (n = 21) |
No prior CPI + PTCy (n = 40) |
No prior CPI + no PTCy (n = 42) |
---|---|---|---|---|
6-month OS, % (95% CI) |
81 (51–94) |
60 (36–78) |
— |
— |
6-month PFS, % (95% CI) |
81 (51–94) |
50 (27–69) |
— |
— |
6-month NRM, % (95% CI) |
14 (4–51) |
25 (12–53) |
— |
— |
1-year OS, % (95% CI) |
83 (56–94) |
28 (10–48) |
53 (29–71) |
55 (37–69) |
1-year PFS, % (95% CI) |
40 (15–64) |
23 (7–43) |
50 (28–69) |
44 (28–59) |
Table 3. Incidence of aGvHD2
Allo-HCT, allogeneic hematopoietic cell transplantation; CPI, checkpoint inhibitor; aGvHD, acute graft-versus-host disease; PTCy, posttransplant cyclophosphamide |
||||||
Patients |
Patients not treated with CPI |
Patients treated with CPI |
|
|||
---|---|---|---|---|---|---|
|
Incidence, % |
95% CI |
Incidence, % |
95% CI |
HR |
95% CI |
Day 100 Grade 2–4 aGvHD |
||||||
Overall |
49 |
(39–62) |
49 |
(35–68) |
0.9 |
0.5–1.6 |
PTCy |
52 |
(38–71) |
44 |
(26–75) |
0.7 |
0.3–1.6 |
No PTCy |
47 |
(34–66) |
54 |
(35–82) |
1.1 |
0.5–2.4 |
Day 100 Grade 3–4 aGvHD |
||||||
Overall |
3 |
(1–10) |
13 |
(6–30) |
5.2 |
0.9–27 |
PTCy |
3 |
(1–19) |
5 |
(1–35) |
2.0 |
0.1–31 |
No PTCy |
3 |
(1–18) |
22 |
(9–51) |
8.5 |
0.9–79 |
Both studies confirm that the use of CPI prior to allo-HSCT favors the development of GvHD, possibly due to the persistent presence of CPI after transplantation, generating enhanced T-cell activation. Juan Nieto and colleagues demonstrated that the extent of T-cell activation is dependent on the GvHD prophylactic regimen used, and can be alleviated, to a degree, with PTCy treatment in patients with NHL. Similarly, Betül Oran et al, reported encouraging data that supports the use of PTCy as a GvHD prophylaxis to decrease GvHD incidence whilst maintaining the graft-versus-leukemia effect in patients with AML/MDS who received CPI before undergoing allo-HCT, which appears to lead to improved transplantation outcomes.
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