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Butyrate is a short chain fatty acid and represents a preferred energy source for the gut epithelium; it is also a histone deacetylase inhibitor and agonist for peroxisome proliferator-activated receptors. Butyrate is secreted by butyrogenic bacteria and its administration, in mice, after allogeneic hematopoietic cell transplant (allo-HCT) improved intestinal epithelial cells junctional integrity and decreased apoptosis and the severity of graft-versus-host disease (GvHD), suggesting that microbial metabolites can mitigate GvHD.1
In this paper, Jonathan L. Golob, Division of Infectious Diseases, Department of Medicine, University of Michigan, Ann Arbor, MI, and colleagues investigated the role of butyrogenic organisms in the development of steroid-refractory acute GvHD (SR-aGvHD), associated with high morbidity and mortality, or chronic GvHD (cGvHD) of the gut.2 Although butyrate has positive effects on the gut, its presence in the context of colitis inhibits healing of the murine gut.3 Thus, response to butyrate could be helpful or harmful in relation to the status of the colonic mucosa.
Study design and patients2
Results2
Conclusion
Butyrate is helpful in prevention of aGvHD1 but its presence after the onset of severe aGvHD of the gut affects the formation of a tight epithelial and impairs colonic mucosal recovery from aGvHD.2 Thus, once aGvHD has started, butyrogens may lead to increased risk for SR-aGvHD and potentially cGvHD.2 Therefore, microbiota-derived metabolites that are beneficial in health can lead to worsened outcomes after the onset of the disease. However, a butyrogen in the stool can be inactive and carefully preserved specimens are required to measure butyrate levels.
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