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In a recent issue of Bone Marrow Transplantation, Helene M. Schoemans, Stephanie J. Lee, James L. Ferrara, Daniel Wolff, John E. Levine, Kirk R. Schultz, Bronwen E. Shaw, Mary E. Flowers, Tapani Ruutu, Hildegard Greinix, Ernst Holler, Grzegorz Basak, Rafael F. Duarte, and Steven Z. Pavletic published a position statement that reviews the current guidelines and terminology regarding acute and chronic graft-verus-host disease (GvHD) on behalf of the EBMT (European Society for Blood and Marrow Transplantation) Transplant Complications Working Party and the “EBMT−NIH (National Institutes of Health)−CIBMTR (Center for International Blood and Marrow Transplant Research) GvHD Task Force.”
The review is intended to support transplantation societies in managing patients affected by, or suspected of having GvHD and also proposing consensus definitions for numerous key terms based on currently available guidelines such as the Mount Sinai Acute GvHD International Consortium (MAGIC) criteria for acute GvHD and the NIH 2014 criteria for chronic GvHD.
The authors stated that they believe that “adherence to a common set of GvHD assessment criteria is vitally important to improve the quality of data, compare results of retrospective studies and prospective clinical trials, and make therapeutic recommendations based on quality evidence. To assist the dissemination of these recommendations, a web-application based on this position statement is available (https://www.uzleuven.be/egvhd).”
In summary, the authors support the use of the MAGIC criteria for aGvHD assessment, and the NIH 2014 criteria for cGvHD diagnosis as these are the most up-to-date and comprehensive guidelines to date. The full article can be found here for more information: https://www.nature.com/articles/s41409-018-0204-7.
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