Management of drug-related adverse events in patients with steroid-refractory cGvHD

During the GvHD Hub Steering Committee Meeting in May 2024, key opinion leaders met to discuss the management of drug-related adverse events in patients with steroid-refractory chronic graft-versus-host disease (cGvHD). The recorded discussion was chaired by Zinaida Peric, and featured Yi-Bin Chen, Amin Alousi, Florent Malard, Mohamad Mohty, Arnon Nagler, Steven Pavletic, and Robert Zeiser.

The steering committee discussed how to define steroid intolerance and how this definition can change for each patient based on side effects and treatment scheduling. In addition, the steering committee spoke about how to approach steroid tapering and appropriate dosing of steroids, and how to evaluate the response of steroids and to ruxolitinib. They also discussed the choice of drug for cGvHD, taking patient factors and side effects into account.