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Itacitinib and corticosteroids for chronic GvHD

Jan 6, 2023
Learning objective: After reading this article, learners will be able to cite a new clinical development in chronic GvHD.

During the 64th American Society of Hematology (ASH) Annual Meeting and Exposition, the GvHD Hub was pleased to speak to Annie Im, University of Pittsburgh, Pittsburgh, US. We asked about itacitinib and corticosteroids for chronic graft-versus-host disease.

Itacitinib and corticosteroids for chronic GvHD

Im opens by discussing steroid treatment, which remains the standard of care, and the need for improved therapied based on disease outcomes. Im goes on to outline itacitinib, a JAK1 inhibitor, as a potential new treatment which could be used either alone or in combination with steroids. Im then discusses results from the GRAVITAS-309 trial, including the overall response and adverse events. Finally, Im summarizes the study conclusions on the future of combination treatments involving itacitinib and corticosteroids.