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Extracorporeal photopheresis (ECP) is commonly used either in combination with infliximab or monotherapy as second- or third-line therapy for patients with graft-versus-host disease (GvHD) who are dependent or refractory to steroids. Ioanna Sakellari et al. from George Papanikolaou Hospital, Thessaloniki, Greece, prospectively evaluated the safety and efficacy of ECP as a second- or third-line treatment in patients with GvHD treated at their center. The study was published ahead of print in the Journal of Clinical Apheresis.
The primary endpoints of the study included overall response rate (ORR) and overall survival (OS). Secondary endpoints were incidences of infections during early post-transplant period and transplant-related mortality (TRM).
In summary, this study indicates that ECP is safe and effective for the treatment of GvHD, especially if it is administered early. The study group stated that “because available data do not favor one agent for second-line therapy of GVHD above another, our results suggest that its choice should be based on potential toxicity, physician experience, and availability of the treatment.”
Key considerations for the use of ECP in GvHD
On November 29, 2022, the GvHD Hub held a virtual symposium on the role of ECP in the management of GvHD. Here, we share the presentation by Mohamad Mohty, Hôpital Saint-Antoine and Sorbonne Université,...
What is extracorporeal photopheresis?
The GvHD Hub held a virtual symposium on the role of ECP in the management of GvHD. Here, we share the presentation given by Professor Hildegard Greinix, which considered ECP and how it works.
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