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Can the combination of HDAC inhibitor panobinostat plus tacrolimus and sirolimus reduce aGVHD?
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During the 46th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the GvHD Hub spoke to Lia Perez, Moffitt Cancer Center, Tampa, US. We asked, Can the combination of HDAC inhibitor panobinostat plus tacrolimus and sirolimus reduce aGVHD?
Can the combination of HDAC inhibitor panobinostat plus tacrolimus and sirolimus reduce aGVHD?
Lia Perez discusses findings of a preliminary study in which panobinostat, a histone deacetylase (HDAC) inhibitor, was tested for the ability to prevent GvHD. The maximum tolerated dose was established by the team and positive results were obtained in terms of GvHD response. Following on from these data, the group investigated a combination of panobinostat with tacrolimus and sirolimus for reducing rates of acute (a)GvHD.
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