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What is the role of human beta-defensin-2 in modulation of the microbiome and aGvHD?

Jul 1, 2022
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Learning objective: After reading this article, learners will be able to cite a new clinical development in acute GvHD.

During the EHA 2022 Congress, the GvHD Hub was pleased to speak to Robert Zeiser, Medical Center – University of Freiburg, Freiburg, DE. We asked, What is the role of human beta-defensin-2 (HBD-2) in modulation of the microbiome and acute GvHD (aGvHD)?

What is the role of human beta-defensin-2 in modulation of the microbiome and aGvHD?

Zeiser begins by discussing the high frequency of patients who develop aGvHD despite receiving prophylaxis. Zeiser also talks about the antimicrobial, immunosuppressive, and immunomodulatory functions of HBD-2, and how it can affect GvHD development and severity.