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What is the latest update on the GRAVITAS-309 trial?

Dec 14, 2022
Learning objective: After reading this article, learners will be able to cite a new clinical development in chronic GvHD.

During the 64th American Society of Hematology (ASH) Annual Meeting and Exposition, the GvHD Hub was pleased to speak to Robert Zeiser, University of Freiburg, Freiburg, DE. We asked, What is the latest update on the GRAVITAS-309 trial?

What is the latest update on the GRAVITAS-309 trial?

In this interview, Zeiser presents the initial results from ASH abstract #771: ‘Itacitinib and Corticosteroids As initial Treatment for Chronic Graft-Versus-Host Disease: Phase 1/2 Results from Gravtias-309.’

Firstly, Zeiser discusses how the anti-inflammatory properties of itacitinib as a JAK 1 inhibitor may be beneficial in chronic GvHD. He goes on to outline the overall efficacy and safety of itacitinib in combination with corticosteroids.