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What is the latest update on biomarkers for assessing GvHD?

During the 2022 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR (Tandem Meetings), the GvHD Hub was pleased to speak to Carrie L. Kitko, Vanderbilt University Medical Center, Nashville, US. We asked, What is the latest update on biomarkers for assessing GvHD?

What is the latest update on biomarkers for assessing GvHD?

Kitko begins by explaining how treatment response at Day 28 is used as a surrogate marker for long-term outcomes in clinical trials, despite limited accuracy. Kitko then discusses the Mount Sinai Acute GvHD International Consortium (MAGIC) algorithm, which can be used to estimate a patient's probability of 6-month nonrelapse mortality. Finally, Kitko talks about potential new biomarkers that were discussed at the Tandem Meetings.