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Divaya Bhutani from Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA, and colleagues retrospectively analyzed the relationship between clostridium difficile infection (CDI) and acute gastrointestinal graft-versus-host disease (GI GvHD) in patients undergoing allogeneic stem cell transplantation (allo-SCT). The study was published ahead of print in Bone Marrow Transplantation.
Data is given as group 1 vs group 2
In summary, this retrospective study found that patients who develop CDI in the post-transplant period have an increased risk of acute GI GvHD. “The highest incidence of CDI is during pre-engraftment period within the first 2 weeks after transplantation, which correlates with the duration of neutropenia and antibiotic use. In addition, CDI can complicate therapy of GI GVHD with increased incidence with use of systemic steroids.”
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