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On 21 February 2019, Jacqueline W. Mays from the National Institutes of Health, Bethesda, MD, USA, presented results on behalf of colleagues of a study evaluating whole saliva for the presence of a diagnostic biomarker profile at first onset of oral chronic graft-versus-host disease (cGvHD) prior to initiation of topical steroid therapy at the 2019 TCT Transplantation and Cellular Therapy Meetings of ASBMT and CIBMTR in Houston, Texas, USA.
Jacqueline W. Mays concluded that ZG16B is present in lower amounts in unstimulated whole saliva and within the salivary gland acinar units at oral cGvHD onset. Reduction in the ZG16B protein may indicate cGvHD activity as well as potentially causing salivary gland damage. Dr. Mays added that further investigation in a larger cohort is required to assess whether saliva can be used to identify a diagnostic biomarker profile for oral cGvHD.
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