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Armin Rashidi and colleagues from the University of Minnesota, Minneapolis, MN, USA, evaluated serum biomarkers of gut barrier as predictors of allogenic hematopoietic stem cell transplantation (allo-HSCT) outcomes. Three biomarkers (citrulline, regenerating islet-derived protein 3 alpha [Reg3a], and intestinal fatty acid binding protein [I-FABP]) were assessed pre-transplant on day -7, and then post-transplant on days 7 and 28 in consecutive patients undergoing allo-HSCT. The results of the study were published ahead of print in Biology of Blood and Marrow Transplantation on 6 July 2018.
Rashidi and colleagues concluded that these findings support that pre-HSCT serum citrulline level can serve as a predictive marker for patients with high risk for developing acute graft-versus-host disease. They further added that their results “suggest that pre-HSCT interventions to augment the gut barrier may decrease the risk of aGvHD.”
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