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Intestinal acute graft-versus-host disease (i-aGvHD) is a serious complication during the first 100 days after allogeneic hematopoietic stem cell transplantation (HSCT). Diagnosis of i-aGvHD is based on clinical symptoms and CT imaging but endoscopic evaluation with histologic and microbiologic examination of the biopsied tissue is necessary to confirm the diagnosis. There is a paucity of data on the efficacy of magnetic resonance enterography (MRE) detecting i-aGvHD. Francesca Maccioni from Sapienza University, Rome, Italy, on behalf of her colleagues presented results of their retrospective analysis investigating the clinical significance of MRE in i-aGvHD diagnosis during an oral abstract session at the 44th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), Lisbon, Portugal, on Wednesday 21 March 2018.
Thirty-five patients (age = 9-69 years) who had suspected i-aGvHD and had a MRE exam between 2015-2017 were included in the analysis. 1.5 Tesla scanner (Siemens, MagnetomAvanto) with 16-channels phased-array coils was used to perform the test.
To accurately assess the severity of i-aGvHD, a score system for all intestinal segments (from stomach to rectum) was implemented based on the following factors:
Francesca Maccioni concluded her talk by highlighting that MRE is efficient in terms of diagnosis of i-aGvHD. She further added that “this technic should be considered to replace invasive methods like endoscopic biopsy.”
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