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On Saturday 1 December, an oral session was held and entitled: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution: GVHD Grading and Outcomes and Management at the 60th American Society of Hematology (ASH) Annual Meeting, held in San Diego, California, from 1–4 December 2018. During this session, an oral abstract was presented by Amit Kalra, University of Calgary, Calgary, AB, Canada. The title of the talk was: Early Prediction of Moderate-Severe Chronic GvHD By Immunity Related Transcriptome.
Amit Kalra and colleagues retrospectively studied the transcriptome of immunity related genes at one month post-transplant in order to evaluate a potential early and accurate predictor of clinically significant chronic graft-versus-host disease (cGvHD).
An ideal cGvHD identifier should be able to predict cGvHD in the first month post-transplant as pre-emptive treatment is efficacious if given early before symptoms appear. An ideal cGvHD identifier should be highly sensible so every high-risk patient can be treated, it should also provide high specificity so every low-risk patient is spared from the toxicity of treatment.
Amit Kalra concluded by stating that this study “provided an early prediction of moderate-severe cGvHD at one month with high sensitivity and specificity.” This method of transcriptome profiling has the potential to be used in every day clinical practice.
To listen to Amit Kalra discussing this study click here.
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