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2023-10-20T11:08:37.000Z

Visual abstract | A phase II trial of CD24Fc for GvHD prophylaxis

By Ella Dixon, Louise Niven
Oct 20, 2023
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Learning objective: After reading this article, learners will be able to cite a new clinical development in GvHD.

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The GvHD Hub is pleased to present a visual abstract representing data from a phase II trial (NCT02663622) evaluating CD24Fc, a novel CD24 fusion protein, for graft-versus-host disease prophylaxis.1

This study, which was conducted in two parts (a double-blind dose-escalation phase and an open-label extension phase), evaluated the safety, recommended dose, and efficacy of CD24Fc in patients undergoing allogeneic hematopoietic stem cell transplantation.1 Overall, CD24Fc demonstrated improved graft-versus-host disease-free survival compared with matched controls, and no patients experienced dose-limiting toxicities.1


 

Visual abstract

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  1. Magenau J, Jaglowski S, Uberti J, et al. A phase 2 trial of CD24Fc for prevention of graft-vs-host disease. Blood. 2023. Online ahead of print. DOI: 1182/blood.2023020250

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CD24FcGraft-versus-host diseaseVisual abstracts

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