All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional.
The gvhd Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the gvhd Hub cannot guarantee the accuracy of translated content. The gvhd and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The GvHD Hub is an independent medical education platform, sponsored by Medac and supported through grants from Sanofi and Therakos. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out more
Create an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View gvhd content recommended for you
What is the mechanism of action of the GLP-2 analog, teduglutide, for GvHD treatment?
Featured:
Robert ZeiserDuring the 47th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the GvHD Hub spoke to Robert Zeiser, Medical Center – University of Freiburg, Freiburg, DE. We asked, What is the mechanism of action of the GLP-2 analog, teduglutide, for GvHD treatment?
What is the mechanism of action of the GLP-2 analog, teduglutide, for GvHD treatment?
In this video, Zeiser explains the mechanism of action of glucagon-like peptide-2 (GLP-2), an enteroendocrine peptide produced by L cells. Studies in mice have shown intestinal GLP-2 levels are reduced in acute (a)GvHD, and similarly in patients developing GvHD. The use of the GLP-2 analog, teduglutide, reduces de novo aGvHD and steroid-refractory aGvHD in different mouse models. Teduglutide may also be effective in patients with steroid-refractory aGvHD.