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What are the main challenges when evaluating novel agents for GvHD prophylaxis?

During the EHA2021 Virtual Congress, the GvHD Hub spoke with Robert Zeiser, Medical Center - University of Freiburg, Freiburg, DE. We asked, What are the main challenges when evaluating novel agents for GvHD prophylaxis?

What are the main challenges when evaluating novel agents for GvHD prophylaxis?

The main challenge identified by Zeiser is that only a small percentage of patients on prophylaxis treatment develop GvHD, making large trials challenging. In addition, the conditioning regimens used in different institutions vary, making it difficult to compare data from trials.

 

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