How can we use microbial-derived metabolites to prevent GvHD?

During the 47th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the GvHD Hub spoke to Erik Thiele Orberg, Technical University of Munich, Munich, DE. We asked, How can we use microbial-derived metabolites to prevent GvHD?

Microbial-derived metabolites are small, easily synthesized molecules that may offer the same benefits as fecal microbiota transplant, without concerns for transmitting infectious diseases, like COVID-19. Orberg envisions that metabolites could be administered prophylactically to patients undergoing stem cell transplantation.